The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro
Abstract Background Fragile X syndrome (FXS), the leading cause of inherited mental retardation, is due to expansion and methylation of a CGG sequence iphone 14 price arizona in the FMR1 gene, which result in its silencing and consequent absence of FMRP protein.This absence causes loss of repression of metabotropic glutamate receptor 5 (mGluR5)-med